The KANK2 gene provides instructions for making a protein called SRC-interacting protein (SIP). SIP regulates proteins called steroid receptor coactivators (SRCs), which play critical roles in turning on (activating) certain genes. Within cells, SIP attaches (binds) to SRCs in the fluid surrounding the nucleus (the cytoplasm). By holding SRCs in the cytoplasm, SIP prevents these proteins from entering the nucleus to activate genes. In this way, SIP helps to control gene activity.
SIP is found in many organs and tissues, including the skin and kidneys. Little is known about its specific roles in various parts of the body.
Other Names
ANKRD25; ankyrin repeat domain 25; ankyrin repeat domain-containing protein 25; KIAA1518; kidney ankyrin repeat-containing protein 2; matrix-remodeling-associated protein 3; matrix-remodelling associated 3; MXRA3; PPKWH; SIP; SRC-1 interacting protein; SRC-1-interacting protein; SRC-interacting protein; SRC1-interacting protein
Related Genetics Topics
Identifiers
- NCBI Gene: 25959
- OMIM: 614610
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
