The KRT4 gene provides instructions for making a protein called keratin 4. Keratins are a group of tough, fibrous proteins that form the structural framework of epithelial cells, which are cells that line the surfaces and cavities of the body. Keratin 4 is found in the moist lining (mucosae) of the mouth, nose, esophagus, genitals, and anus.
Keratin 4 partners with a similar protein, keratin 13 (produced from the KRT13 gene), to form molecules known as intermediate filaments. These filaments assemble into strong networks that provide strength and resilience to the different mucosae. Networks of intermediate filaments protect the mucosae from being damaged by friction or other everyday physical stresses.
Other Names
CK-4; CK4; CYK4; cytokeratin 4; K4; keratin 4, type II; keratin, type II cytoskeletal 4; type-II keratin Kb4
Related Genetics Topics
Identifiers
- NCBI Gene: 3851
- OMIM: 123940
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
