The LIPA gene provides instructions for producing an enzyme called lysosomal acid lipase. This enzyme is found in cell compartments called lysosomes, which digest and recycle materials the cell no longer needs. Lysosomal acid lipase breaks down fats (lipids) such as triglycerides and cholesteryl esters. Cholesteryl esters are made up of two lipids that are attached to each other, cholesterol and a fatty acid. Lysosomal acid lipase separates the cholesterol from the fatty acid. Triglycerides are stored fats that can be broken down into fatty acids that are used for energy. The lipids produced from these processes are used by the body or transported to the liver for removal.
Other Names
cholesterol ester hydrolase; LAL; LICH_HUMAN; lipase A; lipase A, lysosomal acid; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase; sterol esterase
Related Genetics Topics
Identifiers
- NCBI Gene: 3988
- OMIM: 613497
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
