The LTBP4 gene provides instructions for making a protein that has multiple functions in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells. The LTBP4 protein controls the activity of a protein called transforming growth factor beta-1 (TGFβ-1) by attaching it to the extracellular matrix. This growth factor is turned off (inactivated) when stored in the extracellular matrix and turned on (activated) when released. When turned on, the TGFβ-1 protein triggers chemical signals that direct the functions of the body’s cells during growth and development and that regulate the formation of the extracellular matrix.
The LTBP4 protein also plays a critical role in the formation of elastic fibers in the extracellular matrix. Elastic fibers are slender bundles of proteins that provide strength and flexibility to connective tissue, which supports organs and tissues such as the skin, lungs, heart, ligaments, and blood vessels.
Other Names
FLJ46318; FLJ90018; LTBP-4; LTBP-4L
Related Genetics Topics
Identifiers
- NCBI Gene: 8425
- OMIM: 604710
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
