The LZTR1 gene provides instructions for making a protein whose exact function is unknown. The LZTR1 protein is made in cells throughout the body. Within cells, it is found in the Golgi apparatus, which is a structure in which newly produced proteins are modified. Studies suggest that the LZTR1 protein may help stabilize this structure. Researchers suspect that this protein may also be associated with the CUL3 ubiquitin ligase complex, which is part of the cell machinery that breaks down (degrades) unneeded proteins.
Based on its role in several tumor types, the LZTR1 protein is thought to act as a tumor suppressor. Tumor suppressors are proteins that keep cells from growing and dividing too rapidly or in an uncontrolled way.
Other Names
BTBD29; leucine-zipper-like transcriptional regulator 1; LZTR-1; NS10; SWNTS2
Related Genetics Topics
Identifiers
- NCBI Gene: 8216
- OMIM: 137800
- OMIM: 600574
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
