The MAP2K1 gene provides instructions for making a protein known as MEK1 protein kinase. This protein is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell’s nucleus. RAS/MAPK signaling helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). MEK1 protein kinase appears to be essential for normal development before birth and for survival after birth.
Other Names
Dual Specificity Mitogen-Activated Protein Kinase Kinase 1; ERK Activator Kinase 1; MAP Kinase Kinase 1; MAPK/ERK kinase 1; MAPKK1; MEK-1; MEK-1 Protein Kinase; MEK1; MKK-1 Protein Kinase; MKK1; MKK1 Protein Kinase; MP2K1_HUMAN; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
Related Genetics Topics
- Noonan syndrome — MedlinePlus Genetics
- Cardiofaciocutaneous syndrome — MedlinePlus Genetics
- Noonan syndrome with multiple lentigines — MedlinePlus Genetics
- Langerhans cell histiocytosis — MedlinePlus Genetics
- Lung cancer — MedlinePlus Genetics
- Melorheostosis — MedlinePlus Genetics
Identifiers
- NCBI Gene: 5604
- OMIM: 176872
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
