The MATR3 gene provides instructions for making a protein called matrin 3, which is found in the nucleus of the cell as part of the nuclear matrix. The nuclear matrix is a network of proteins that provides structural support for the nucleus and aids in several important nuclear functions.
The function of the matrin 3 protein is unknown. This protein can attach to (bind) RNA, which is a chemical cousin of DNA. Some studies indicate that matrin 3 binds and stabilizes a type of RNA called messenger RNA (mRNA), which provides the genetic blueprint for proteins. Matrin 3 may also bind certain abnormal RNAs that could lead to nonfunctional or harmful proteins, thereby blocking the formation of such proteins. Other studies suggest that the matrin 3 protein may be involved in cell survival.
Other Names
MATR3_HUMAN; matrin-3; matrin-3 isoform a; matrin-3 isoform b; MGC9105; MPD2
Related Genetics Topics
Identifiers
- NCBI Gene: 9782
- OMIM: 164015
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
