The MED13L gene provides instructions for making a protein that is one piece (subunit) of a group of proteins known as the mediator complex. This complex regulates the activity (transcription) of genes. Transcription is the first step in the process by which information stored in a gene’s DNA is used to build proteins.
The mediator complex physically links the proteins that can turn genes on, called transcription factors, with the enzyme that carries out transcription, called RNA polymerase II. Once transcription factors are attached to RNA polymerase II, transcription begins.
Researchers believe that as part of the mediator complex, the MED13L protein is involved in many aspects of early development, including development of the heart, nerve cells (neurons) in the brain, and structures in the face. The mediator complex plays a role in several chemical signaling pathways within cells. These pathways help direct a broad range of cellular activities, such as cell growth, cell movement (migration), and the process by which cells mature to carry out specific functions (differentiation).
Other Names
KIAA1025; MEDIATOR COMPLEX SUBUNIT 13-LIKE; PROSIT240; PROTEIN SIMILAR TO TRAP240; THRAP2; THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN 2; TRAP240-LIKE PROTEIN; TRAP240L
Related Genetics Topics
Identifiers
- NCBI Gene: 23389
- OMIM: 608771
- OMIM: 608808
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
