The MFN2 gene provides instructions for making a protein called mitofusin 2. This protein helps determine the shape and structure (morphology) of mitochondria, the energy-producing centers within cells. Mitofusin 2 is made in many types of cells and tissues, including muscles, the spinal cord, and the nerves that connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound (peripheral nerves).
Within cells, mitofusin 2 is found in the outer membrane that surrounds mitochondria. Mitochondria are dynamic structures that undergo changes in morphology through processes called fission (splitting into smaller pieces) and fusion (combining pieces). These changes in morphology are necessary for mitochondria to function properly. Mitofusin 2 helps to regulate the morphology of mitochondria by controlling the fusion process.
Other Names
CMT2A2; CPRP1; KIAA0214; MARF; MFN2_HUMAN; mitochondrial assembly regulatory factor
Related Genetics Topics
Identifiers
- NCBI Gene: 9927
- OMIM: 601152
- OMIM: 608507
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
