The MPZ gene provides instructions for making a protein called myelin protein zero. It is the most abundant protein in myelin, a protective substance that covers nerves and promotes the efficient transmission of nerve impulses. Myelin protein zero is produced by specialized cells called Schwann cells, which wrap around and insulate peripheral nerves. Peripheral nerves connect the brain and spinal cord to muscles and to sensory cells that detect sensations such as touch, pain, heat, and sound. Myelin protein zero is required for the proper formation and maintenance of myelin. This protein is an adhesion molecule, which means it acts like molecular glue. It plays a role in tightly packing the myelin around nerve cells (myelin compaction).
Other Names
CMT1B; CMT2I; CMT2J; HMSN1B; MPP; myelin glycoprotein P-zero; myelin peripheral protein; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B); MYP0_HUMAN; P0 Glycoprotein; P0 Protein
Related Genetics Topics
Identifiers
- NCBI Gene: 4359
- OMIM: 159440
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
