The MSH6 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps correct errors that are made when DNA is copied in preparation for cell division, a process called DNA replication. The MSH6 protein joins with another protein called MSH2 to form a two-protein complex called a dimer. This complex identifies locations where errors have been made during DNA replication. The MSH2-MSH6 dimer, together with another dimer and additional proteins, makes the repairs by replacing the section of DNA that contains an error with a corrected DNA sequence. The MSH6 gene is one of a set of genes called mismatch repair (MMR) genes.
Other Names
G-T binding protein; G/T mismatch-binding protein; GTBP; MSH-6
Related Genetics Topics
- Lynch syndrome — MedlinePlus Genetics
- Constitutional mismatch repair deficiency syndrome — MedlinePlus Genetics
Identifiers
- NCBI Gene: 2956
- OMIM: 600678
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
