The NLRP12 gene provides instructions for making a protein called monarch-1. Monarch-1 is a member of a family of proteins called intracellular “NOD-like” receptor (NLR) proteins. Monarch-1 is found mainly in certain types of white blood cells.
NLR proteins are involved in the immune system, helping to control the immune system’s response to injury, toxins, or foreign invaders. The monarch-1 protein is involved in an immune process known as inflammation. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight foreign invaders and help with tissue repair. After this has been accomplished, stopping the inflammatory response helps to prevent damage to the body’s own cells and tissues.
Monarch-1 primarily stops (inhibits) inflammation by blocking the release of specific molecules that are involved in the process. However, monarch-1 can also promote the production of proteins that trigger inflammation when certain molecules are present.
Other Names
monarch 1; Monarch1; NACHT, leucine rich repeat and PYD containing 12; NACHT, LRR and PYD containing protein 12; NALP12; NLR family, pyrin domain containing 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; PAN6; PYPAF7; PYRIN-containing APAF1-like protein 7
Related Genetics Topics
- Familial cold autoinflammatory syndrome — MedlinePlus Genetics
- Familial cold autoinflammatory syndrome type 2 — MedlinePlus Genetics
Identifiers
- NCBI Gene: 91662
- OMIM: 609648
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
