The NSD1 gene provides instructions for making a protein that functions as a histone methyltransferase. Histone methyltransferases are enzymes that modify structural proteins called histones, which attach (bind) to DNA and give chromosomes their shape. By adding a molecule called a methyl group to histones (a process called methylation), histone methyltransferases control (regulate) the activity of certain genes and can turn them on and off as needed. The NSD1 enzyme controls the activity of genes involved in normal growth and development, although most of these genes have not been identified.
Other Names
androgen receptor-associated coregulator 267; ARA267; histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; NR-binding SET domain containing protein; NSD1_HUMAN; nuclear receptor-binding Su-var, Enhancer of zeste and Trithorax domain protein 1; SOTOS1
Related Genetics Topics
Identifiers
- NCBI Gene: 64324
- OMIM: 601626
- OMIM: 606681
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
