The NTN1 gene provides instructions for making a protein called netrin-1, which is involved in the development of the nervous system. This protein attaches (binds) to a protein called netrin-1 receptor, and these two proteins fit together like a lock and key. The binding of netrin-1 to its receptor helps direct the growth of specialized nerve cell extensions called axons. Axons transmit nerve impulses that can signal muscle movement.
When the brain sends a signal to trigger muscle movement, the signal usually travels from one half of the brain to the opposite side of the body. Binding netrin-1 to its receptor allows axons to develop this signaling pathway.
Other Names
MRMV4; NET1; NTN1L
Related Genetics Topics
Identifiers
- NCBI Gene: 9423
- OMIM: 601614
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
