The OAT gene provides instructions for making the enzyme ornithine aminotransferase. This enzyme is active in the energy-producing centers of cells (mitochondria), where it helps break down a molecule called ornithine. Ornithine is involved in the urea cycle, which processes excess nitrogen (in the form of ammonia) that is generated when protein is broken down by the body.
In addition to its role in the urea cycle, ornithine participates in several reactions that help ensure the proper balance of protein building blocks (amino acids) in the body. This balance is important because a specific sequence of amino acids is required to build each of the many different proteins needed for the body’s functions. The ornithine aminotransferase enzyme helps convert ornithine into another molecule called pyrroline-5-carboxylate (P5C). P5C can be converted into the amino acids glutamate and proline.
Other Names
DKFZp781A11155; HOGA; OAT_HUMAN; ornithine aminotransferase (gyrate atrophy); ornithine aminotransferase precursor
Related Genetics Topics
Identifiers
- NCBI Gene: 4942
- OMIM: 613349
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
