The PGM3 gene provides instructions for making an enzyme called phosphoglucomutase 3 (PGM3). This enzyme is involved in a process called glycosylation. During this process, complex chains of sugar molecules (oligosaccharides) are added to proteins and fats (lipids). Glycosylation modifies proteins and lipids so they can perform a wider variety of functions.
The PGM3 enzyme converts a molecule called N-acetylglucosamine-6-phosphate into a different molecule called N-acetylglucosamine-1-phosphate. This conversion is required to make a sugar called uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), which is needed to transfer sugars to growing oligosaccharides during glycosylation.
Other Names
acetylglucosamine phosphomutase; AGM1; N-acetylglucosamine-phosphate mutase 1; PAGM
Related Genetics Topics
Identifiers
- NCBI Gene: 5238
- OMIM: 172100
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
