The PIGT gene provides instructions for making a protein called GPI transamidase component PIG-T (shortened to PIG-T protein). This protein is important for the attachment of certain proteins to the cell surface. Specifically, the PIG-T protein attaches (binds) a molecule called a glycosylphosphatidylinositol (GPI) anchor to various proteins inside the cell. After the GPI anchor and protein are bound, the anchor is attached to the outer surface of the cell membrane. Anchored proteins have a variety of roles, including sticking cells to one another, relaying signals into cells, and protecting cells from destruction.
Other Names
CGI-06; MCAHS3; NDAP; neuronal development-associated protein; phosphatidylinositol glycan, class T; PNH2
Related Genetics Topics
Identifiers
- NCBI Gene: 51604
- OMIM: 610272
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
