The PIK3R2 gene provides instructions for making one piece (subunit) of an enzyme called phosphatidylinositol 3-kinase (PI3K). The primary function of the subunit, which is known as P85β, is to regulate the PI3K enzyme’s activity.
PI3K is a kinase, which means that it adds a cluster of oxygen and phosphorus atoms (a phosphate group) to other proteins through a process called phosphorylation. PI3K phosphorylates certain signaling molecules, which triggers a series of additional reactions as part of a chemical signaling pathway called the PI3K-AKT-mTOR pathway. This signaling influences many critical cell functions, including the creation (synthesis) of new proteins, cell growth and division (proliferation), and the survival of cells. The PI3K-AKT-mTOR pathway is essential for the normal development of many parts of the body, including the brain.
Other Names
p85; p85-BETA; P85B; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta
Related Genetics Topics
Identifiers
- NCBI Gene: 5296
- OMIM: 603157
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
