The PRICKLE1 gene provides instructions for making a protein called prickle homolog 1. The function of this protein is unclear, although it appears to play an important role in the development of the nervous system. Prickle homolog 1 is likely part of a chemical signaling pathway known as noncanonical Wnt signaling. During development before birth, noncanonical Wnt signaling helps to determine the position of various components within cells (cell polarity). This pathway also regulates the movement of nerve cells (neurons) in the developing nervous system.
Studies suggest that prickle homolog 1 interacts with other proteins, including RE1-silencing transcription factor (REST). The REST protein regulates several critical genes in neurons by turning off (suppressing) their activity. To regulate these genes, REST must enter the nucleus and attach (bind) to particular regions of DNA. Researchers believe that prickle homolog 1 controls REST by transporting it out of the nucleus, which prevents it from binding to DNA and suppressing gene activity. It remains unclear how the interaction between prickle homolog 1 and REST contributes to the normal development of the nervous system.
Other Names
EPM1B; FLJ31627; FLJ31937; MGC138902; MGC138903; PRIC1_HUMAN; prickle homolog 1; prickle-like 1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; REST/NRSF-interacting LIM domain protein; RILP
Related Genetics Topics
Identifiers
- NCBI Gene: 144165
- OMIM: 608500
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
