The RAB18 gene provides instructions for producing the RAB18 protein, which functions as a GTPase. Often referred to as molecular switches, GTPases can be turned on and off. They are turned on (active) when they are attached (bound) to a molecule called GTP and are turned off (inactive) when they are bound to another molecule called GDP. When active, RAB18 is involved in a process called vesicle trafficking, which moves proteins and other molecules within cells in sac-like structures called vesicles. RAB18 regulates the movement of substances between compartments in cells and the storage and release of fats (lipids) by structures called lipid droplets. The protein also appears to play a role in a process called autophagy, which helps clear unneeded materials from cells. RAB18 is important for the organization of a cell structure called the endoplasmic reticulum, which is involved in protein processing and transport.
Other Names
RAB18 small GTPase; RAB18LI1; ras-related protein Rab-18 isoform 1; ras-related protein Rab-18 isoform 2; ras-related protein Rab-18 isoform 3; ras-related protein Rab-18 isoform 4; ras-related protein Rab-18 isoform 5; WARBM3
Related Genetics Topics
Identifiers
- NCBI Gene: 22931
- OMIM: 602207
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
