The SALL1 gene is part of a group of related genes that provide instructions for making proteins involved in the formation of tissues and organs before birth. These proteins are transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes.
The SALL1 protein helps turn off (repress) gene activity by interacting with other proteins that alter how tightly regions of DNA are packaged. This process, known as chromatin remodeling, is one way gene expression is regulated during development; typically, when DNA is tightly packed, gene expression is lower than when DNA is loosely packed. By controlling gene activity, the SALL1 protein plays an important role in development of the hands (particularly the thumbs), ears, anus, kidneys, and other parts of the body before birth.
Other Names
HSAL1; sal (Drosophila)-like 1; sal-like 1; sal-like 1 (Drosophila); Sal-like protein 1; SALL1_HUMAN; spalt-like transcription factor 1; TBS; ZNF794
Related Genetics Topics
- Townes-Brocks Syndrome — MedlinePlus Genetics
- Anophthalmia/Microphthalmia — MedlinePlus Genetics
- Coloboma — MedlinePlus Genetics
- Congenital anomalies of kidney and urinary tract — MedlinePlus Genetics
Identifiers
- NCBI Gene: 6299
- OMIM: 602218
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
