The SCN2A gene belongs to a family of genes that provide instructions for making sodium channels. These channels, which transport positively charged atoms (ions) of sodium into cells, play a key role in a cell’s ability to generate and transmit electrical signals.
The SCN2A gene provides instructions for making one part (the alpha subunit) of a sodium channel called NaV1.2. These channels are primarily found in the brain, where they control the flow of sodium ions into nerve cells (neurons). NaV1.2 channels are involved in transmitting signals from one neuron to another. Communication between neurons depends on chemicals called neurotransmitters, which are released from one neuron and taken up by neighboring neurons. The flow of sodium ions through NaV1.2 channels helps determine when neurotransmitters will be released.
Other Names
NAC2; NAV1.2; SCN2A1; SCN2A2; sodium channel, brain type II, alpha subunit; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha subunit; sodium voltage-gated channel, alpha subunit 2
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Identifiers
- NCBI Gene: 6326
- OMIM: 182390
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
