The SH3BP2 gene provides instructions for making a protein whose exact function is unclear, although it is known to interact with other proteins within cells. The SH3BP2 protein plays a role in transmitting chemical signals, particularly in certain immune system cells and cells involved in the replacement of old bone tissue with new bone (bone remodeling).
Studies suggest that the SH3BP2 protein helps regulate signaling pathways that turn on (activate) immune system cells called B cells and macrophages. The protein is also involved in the production of osteoclasts, which are specialized cells that break down bone tissue when it is no longer needed. Osteoclasts play a central role in bone remodeling.
Other Names
3BP-2; 3BP2; 3BP2_HUMAN; CRBM; CRPM; FLJ42079; RES4-23; SH3-domain binding protein 2
Related Genetics Topics
Identifiers
- NCBI Gene: 6452
- OMIM: 602104
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
