The SLC46A1 gene provides instructions for making a protein called the proton-coupled folate transporter (PCFT). This protein is found within the membrane of cells, where it helps transport certain B vitamins called folates into the cell. PCFT is primarily found in cells that line the walls of the small intestine. These cells have fingerlike projections called microvilli that absorb nutrients from food as it passes through the intestine. Based on their appearance, groups of these microvilli are known collectively as the brush border. PCFT is involved in transporting folates from food across the brush border membrane so they can be used by the body. PCFT is also found in the brain, where it is involved in the transport of folates between the brain and the surrounding fluid (cerebrospinal fluid).
Other Names
HCP1; heme carrier protein 1; PCFT; proton-coupled folate transporter; solute carrier family 46 (folate transporter), member 1; solute carrier family 46, member 1
Related Genetics Topics
Identifiers
- NCBI Gene: 113235
- OMIM: 611672
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
