The SP110 gene provides instructions for making a protein called SP110 nuclear body protein, which is a component of cellular structures called nuclear bodies. Nuclear bodies are located within the nuclei of cells, where they help control the activity of certain genes. Nuclear bodies are also involved in the regulation of cell division, the self-destruction of cells that are damaged or no longer needed (apoptosis), and the normal function of the immune system.
SP110 nuclear body protein is active primarily in immune system cells called leukocytes and in the spleen. This protein likely helps regulate the activity of genes that are needed for the body’s immune response to foreign invaders, such as viruses and bacteria.
Approximately seven slightly different versions (isoforms) of the SP110 nuclear body protein may be produced from this gene. These isoforms are different sizes and likely have distinct but similar functions.
Other Names
nuclear body protein SP110; SP110_HUMAN; transcriptional coactivator Sp110
Related Genetics Topics
Identifiers
- NCBI Gene: 3431
- OMIM: 604457
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
