The STAT3 gene is part of a family known as the STAT genes. These genes provide instructions for making proteins that are part of essential chemical signaling pathways within cells. When STAT proteins are turned on (activated) by certain chemical signals, they move into the cell’s nucleus and attach (bind) to particular areas of DNA. The STAT proteins bind to regulatory regions near genes, which allows the proteins to control whether these genes are turned on or off. STAT proteins are called transcription factors on the basis of this action.
Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. It helps control cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis).
The STAT3 protein is active in tissues throughout the body. It plays an important role in the development and function of several body systems and is essential for life. In the immune system, the STAT3 protein transmits signals for the maturation of immune system cells, especially T cells and B cells. These cells help control the body’s response to foreign invaders such as bacteria and fungi.
In addition, the protein is involved in the regulation of inflammation, which is one way the immune system responds to infection or injury, and it plays a role in cellular processes that promote allergic reactions.
In the skeletal system, the STAT3 protein is involved in the formation of specialized cells that build and break down bone tissue. These cells are necessary for the normal development and maintenance of bones.
Other Names
acute-phase response factor; APRF; APRF Transcription Factor; DNA-binding protein APRF; FLJ20882; hypothetical protein MGC16063; IL6-Response Factor; LIF(leukemia inhibitory factor)-Response Factor; LIF-Response Factor; signal transducer and activator of transcription 3 (acute-phase response factor); STAT3_HUMAN
Related Genetics Topics
- Crohn disease — MedlinePlus Genetics
- Autosomal dominant hyper-IgE syndrome — MedlinePlus Genetics
- Autoimmune lymphoproliferative syndrome — MedlinePlus Genetics
- Prostate cancer — MedlinePlus Genetics
- Shingles — MedlinePlus Genetics
Identifiers
- NCBI Gene: 6774
- OMIM: 102582
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
