The TET2 gene provides instructions for making a protein whose function is unknown. Based on the function of similar proteins, researchers believe the TET2 protein is involved in regulating the process of transcription, which is the first step in protein production. Although this protein is found throughout the body, it may play a particularly important role in the production of blood cells from hematopoietic stem cells. These stem cells are located within the bone marrow and have the potential to develop into red blood cells, white blood cells, and platelets. The TET2 protein appears to act as a tumor suppressor, which is a protein that prevents cells from growing and dividing in an uncontrolled way.
Other Names
FLJ20032; KIAA1546; MGC125715; probable methylcytosine dioxygenase TET2; probable methylcytosine dioxygenase TET2 isoform a; probable methylcytosine dioxygenase TET2 isoform b; tet oncogene family member 2; TET2_HUMAN
Related Genetics Topics
- Polycythemia vera — MedlinePlus Genetics
- Primary myelofibrosis — MedlinePlus Genetics
- Essential thrombocythemia — MedlinePlus Genetics
- Systemic mastocytosis — MedlinePlus Genetics
Identifiers
- NCBI Gene: 54790
- OMIM: 612839
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
