The TG gene provides instructions for making a protein called thyroglobulin, one of the largest proteins in the body. This protein is found only in the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroglobulin combines with iodine and is modified and broken down to release small molecules known as thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism). Thyroglobulin also serves as a protein storehouse for iodine and inactive thyroid hormone until these substances are needed.
Other Names
AITD3; TGN; THYG_HUMAN
Related Genetics Topics
- Congenital hypothyroidism — MedlinePlus Genetics
- Hashimoto thyroiditis — MedlinePlus Genetics
- Graves disease — MedlinePlus Genetics
Identifiers
- NCBI Gene: 7038
- OMIM: 188450
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
