The TGM1 gene provides instructions for making an enzyme called transglutaminase 1. This enzyme is found in cells that make up the outermost layer of the skin (the epidermis). Transglutaminase 1 is involved in the formation of the cornified cell envelope, which is a structure that surrounds skin cells and helps form a protective barrier between the body and its environment. Specifically, transglutaminase 1 forms strong bonds, called cross-links, between the structural proteins that make up the cornified cell envelope. This cross-linking provides strength and stability to the epidermis.
Other Names
epidermal TGase; ICR2; protein-glutamine gamma-glutamyltransferase K; TGASE; TGase K; TGase-1; TGK; TGM1_HUMAN; transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); transglutaminase K; transglutaminase, keratinocyte; transglutaminase-1
Related Genetics Topics
Identifiers
- NCBI Gene: 7051
- OMIM: 190195
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
