The TPP1 gene provides instructions for making an enzyme called tripeptidyl peptidase 1. This enzyme is produced as an inactive enzyme, called a proenzyme, which has an extra segment attached. This segment must be removed, followed by additional processing steps, for the enzyme to become active. The active tripeptidyl peptidase 1 enzyme is found in cell structures called lysosomes, which digest and recycle different types of molecules. Tripeptidyl peptidase 1 acts as a peptidase, which means that it breaks down protein fragments, known as peptides, into their individual building blocks (amino acids). Specifically, tripeptidyl peptidase 1 cuts (cleaves) peptides into groups of three amino acids.
Other Names
cell growth-inhibiting gene 1 protein; CLN2; GIG1; growth-inhibiting protein 1; LPIC; lysosomal pepstatin insensitive protease; TPP-1; TPP1_HUMAN; tripeptidyl aminopeptidase; tripeptidyl peptidase I; tripeptidyl-peptidase 1; tripeptidyl-peptidase 1 preproprotein
Related Genetics Topics
Identifiers
- NCBI Gene: 1200
- OMIM: 607998
- OMIM: 609270
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
