The TSHR gene provides instructions for making a protein, known as a receptor, that attaches (binds) to a hormone called thyroid stimulating hormone (TSH). This receptor spans the membrane of certain cells (called follicular cells) in the thyroid gland, a butterfly-shaped tissue in the lower neck. A large part of the receptor sits on the outer surface of the cell (extracellular), and a small portion is retained inside the cell (intracellular). Thyroid stimulating hormone binds to the extracellular portion of the receptor like a key fitting into a lock, activating a series of reactions that control development of the thyroid gland and its functions. Among its functions, the thyroid gland produces iodine-containing hormones (thyroid hormones), which help regulate growth, brain development, and the rate of chemical reactions in the body (metabolism).
Other Names
LGR3; thyrotropin receptor; TSH Receptors; TSHR_HUMAN
Related Genetics Topics
- Congenital hypothyroidism — MedlinePlus Genetics
- Graves disease — MedlinePlus Genetics
Identifiers
- NCBI Gene: 7253
- OMIM: 603372
- OMIM: 609152
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
