The TTR gene provides instructions for making a protein called transthyretin. This protein transports vitamin A (retinol) and a hormone called thyroxine throughout the body. To transport thyroxine, four transthyretin proteins must attach (bind) to each other to form a four-protein unit (tetramer). To transport retinol, transthyretin must form a tetramer and bind to another protein called retinol-binding protein. Transthyretin is produced primarily in the liver, and a small amount of this protein is produced in an area of the brain called the choroid plexus and in the light-sensitive tissue that lines the back of the eye (the retina).
Other Names
ATTR; PALB; prealbumin, amyloidosis type I; TBPA; TTHY_HUMAN
Related Genetics Topics
Identifiers
- NCBI Gene: 7276
- OMIM: 176300
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
