The VLDLR gene provides instructions for making a protein called a very low-density lipoprotein (VLDL) receptor. This protein is active in many different organs and tissues, but it appears to play a particularly important role in the developing brain.
The VLDL receptor works together with a protein called reelin. Reelin fits into the VLDL receptor like a key in a lock, which triggers a series of chemical reactions within the cell. This series of reactions is known as a signaling pathway. During early brain development, the reelin signaling pathway helps guide immature nerve cells (neuroblasts) to their appropriate locations.
Other Names
CARMQ1; CHRMQ1; VLDLRCH
Related Genetics Topics
Identifiers
- NCBI Gene: 7436
- OMIM: 192977
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
