The WNT4 gene belongs to a family of WNT genes that play critical roles in development before birth. WNT genes provide instructions for making proteins that participate in chemical signaling pathways in the body. These pathways control the activity of certain genes and regulate the interactions between cells during embryonic development.
The WNT4 gene provides instructions for producing a protein that is important for the formation of the female reproductive system, the kidneys, and several hormone-producing glands. During the development of the female reproductive system, the WNT4 protein regulates the formation of the Müllerian ducts, which are structures in the embryo that develop into the uterus, fallopian tubes, cervix, and the upper part of the vagina. This protein is also involved in development of the ovaries, from before birth through adulthood, and is important for development and maintenance of egg cells (oocytes) in the ovaries. In addition, the WNT4 protein regulates the production of male sex hormones (androgens).
Other Names
wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4; WNT-4; WNT-4 protein; WNT4_HUMAN
Related Genetics Topics
- Müllerian aplasia and hyperandrogenism — MedlinePlus Genetics
- Dupuytren contracture — MedlinePlus Genetics
- Congenital anomalies of kidney and urinary tract — MedlinePlus Genetics
Identifiers
- NCBI Gene: 54361
- OMIM: 603490
- OMIM: 611812
Source: MedlinePlus Genetics, U.S. National Library of Medicine.
